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This volume brings together a series of review articles that highlight new advances in using the fruit fly, Drosophila melanogaster, to study a wide range of cancer-related topics. Building on the foundation of Volume I, the articles demonstrate how research in Drosophila continues to uncover important developmental, cellular, and molecular mechanisms underlying tumor growth, progression, and systemic interactions. Readers will appreciate how the fly’s simple genetics and powerful experimental tools make it a flexible and effective model for studying cancer. Drosophila offers unique opportunities to answer key questions about how uncontrolled cell proliferation begins and progresses into cancer—questions that can be very difficult to explore in other systems. This book is a valuable resource for researchers interested in using the Drosophila model to better understand cancer biology and to help find new strategies to combat this disease.